Endocrine Abstracts

Objective: Oxidative stress has been implicated in the pathogenesis of hyperthyroidism, and its complications. Advanced glycation end products (AGEs), compounds derived from non-enzymatic transformation of macromolecules, are able to increase oxidative stress and promote inflammation and are increased in several oxidative stress-related disorders, including autoimmune thyroiditis. In the same diseases, the activity of paraoxonase-1 (PON-1), an anti-oxidant enzyme protecting ag...

Background: PCBs are chemical pollutants able to promote inflammation and carcinogenesis. They can accumulate in human tissues through the food chain causing a variety of adverse health effects. The NF-E2 p45-related factor 2 (NRF2) and the aryl hydrocarbon receptor (AHR) are ligand activated transcription factors controlling pathways modulating xenobiotic metabolism. Increasing evidence indicate the involvement of AhR in regulating extracellular matrix (ECM) homeostasis. ECM ...